Heterogeneity-optimized method for predicting immune checkpoint blockade response
Abstract Interpatient tumor heterogeneity manifests as multimodal distributions across genomic, transcriptomic, and microenvironmental profiles. This fundamentally violates the unimodal assumption of conventional machine learning models, impairing immune checkpoint blockade (ICB) response prediction...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2025-09-01
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| Series: | Scientific Reports |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1038/s41598-025-17718-3 |
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