Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone

Abstract DNA mutations in specific genes can confer preferential benefit from drugs targeting those genes. However, other molecular perturbations can “phenocopy” pathogenic mutations, but would not be identified using standard clinical sequencing, leading to missed opportunities for other patients t...

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Auteurs principaux:	Hamza Bakhtiar, Kyle T. Helzer, Yeonhee Park, Yi Chen, Nicholas R. Rydzewski, Matthew L. Bootsma, Yue Shi, Paul M. Harari, Marina Sharifi, Martin Sjöström, Joshua M. Lang, Menggang Yu, Shuang G. Zhao
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2022-10-01
Collection:	npj Genomic Medicine
Accès en ligne:	https://doi.org/10.1038/s41525-022-00328-7
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