AIMP2 accumulation in brain leads to cognitive deficits and blood secretion in Parkinson’s disease

Abstract Background Propagation of neuronal α-synuclein aggregate pathology to the cortex and hippocampus correlates with cognitive impairment in Parkinson’s disease (PD) dementia and dementia with Lewy body disease. Previously, we showed accumulation of the parkin substrate aminoacyl-tRNA synthetas...

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Autors principals:	Heejeong Kim, Jeong-Yong Shin, Sangwoo Ham, Ji Hun Kim, Gum Hwa Lee, Nae-Eung Lee, Hee-Tae Kim, Seok Hyun Cho, Sangseong Kim, Yunjong Lee
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2024-10-01
Col·lecció:	Journal of Translational Medicine
Matèries:	AIMP2 Conditional transgenic mice Lewy body dementia Intercellular protein transmission Blood biomarker Diagnosis
Accés en línia:	https://doi.org/10.1186/s12967-024-05666-x
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