AIMP2 accumulation in brain leads to cognitive deficits and blood secretion in Parkinson’s disease

Abstract Background Propagation of neuronal α-synuclein aggregate pathology to the cortex and hippocampus correlates with cognitive impairment in Parkinson’s disease (PD) dementia and dementia with Lewy body disease. Previously, we showed accumulation of the parkin substrate aminoacyl-tRNA synthetas...

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Detalhes bibliográficos

Principais autores:	Heejeong Kim, Jeong-Yong Shin, Sangwoo Ham, Ji Hun Kim, Gum Hwa Lee, Nae-Eung Lee, Hee-Tae Kim, Seok Hyun Cho, Sangseong Kim, Yunjong Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-10-01
coleção:	Journal of Translational Medicine
Assuntos:	AIMP2 Conditional transgenic mice Lewy body dementia Intercellular protein transmission Blood biomarker Diagnosis
Acesso em linha:	https://doi.org/10.1186/s12967-024-05666-x
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