Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation

Abstract Background Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis. Here we examine 5hmC changes upon progression to liver metasta...

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Bibliografski detalji

Glavni autori:	Ben Murcott, Floris Honig, Dominic Oliver Halliwell, Yuan Tian, James Lawrence Robson, Piotr Manasterski, Jennifer Pinnell, Thérèse Dix-Peek, Santiago Uribe-Lewis, Ashraf E. K. Ibrahim, Julia Sero, David Gurevich, Nikolas Nikolaou, Adele Murrell
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-04-01
Serija:	BMC Biology
Teme:	5-Hydroxymethylcytosine Colorectal cancer progression to metastasis Ten-eleven-translocation (TET) Epigenetics Zebrafish assay
Online pristup:	https://doi.org/10.1186/s12915-025-02205-y
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