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5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Abstract Somatic cell nuclear transfer (SCNT) embryos exhibit widespread epigenetic defects, particularly aberrant DNA methylation. DNA 5‐hydroxymethylcytosine (5hmC) is involved in methylation reprogramming during early embryonic development, yet its role in SCNT embryos remains largely unknown. He...

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Principais autores: Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2026-01-01
coleção:Advanced Science
Assuntos:
5‐hydroxymethylcytosine
embryonic development
epigenetic barrier
somatic cell nuclear transfer
Acesso em linha:https://doi.org/10.1002/advs.202509682
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