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USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency

Abstract Background Premature ovarian insufficiency (POI) is a condition characterized by a substantial decline or loss of ovarian function in women before the age of 40. However, the pathogenesis of POI remains to be further elucidated, and specific targeted drugs which could delay or reverse ovari...

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Principais autores: Lin-Zi Ma, Ao Wang, Yun-Hui Lai, Jun Zhang, Xiao-Fei Zhang, Shi-Ling Chen, Xing-Yu Zhou
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-09-01
Serier:Journal of Translational Medicine
Fag:
Premature ovarian insufficiency
Granulosa cells
Ubiquitin-specific protease 14
DNA damage repair
Cell senescence
Online adgang:https://doi.org/10.1186/s12967-024-05636-3
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