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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

Summary: Immune checkpoint blockade (ICB) therapies display clinical efficacy in microsatellite instable (MSI) endometrial cancer (EC) treatment, the key mechanism of which is reversing T cell exhaustion and restoration of anti-tumor immunity. Here, we demonstrate that transcription factor 19 (TCF19...

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Principais autores: Xinyue Ma, Qiuman Wang, Chenggong Sun, Indu Agarwal, Huan Wu, Jingying Chen, Chen Zhao, Gonghua Qi, Qiuli Teng, Cunzhong Yuan, Shi Yan, Jiali Peng, Rongrong Li, Kun Song, Qing Zhang, Beihua Kong
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2023-08-01
סדרה:Cell Reports
נושאים:
CP: Cancer
CP: Immunology
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2211124723009555
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