Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

Summary: Immune checkpoint blockade (ICB) therapies display clinical efficacy in microsatellite instable (MSI) endometrial cancer (EC) treatment, the key mechanism of which is reversing T cell exhaustion and restoration of anti-tumor immunity. Here, we demonstrate that transcription factor 19 (TCF19...

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主要な著者:	Xinyue Ma, Qiuman Wang, Chenggong Sun, Indu Agarwal, Huan Wu, Jingying Chen, Chen Zhao, Gonghua Qi, Qiuli Teng, Cunzhong Yuan, Shi Yan, Jiali Peng, Rongrong Li, Kun Song, Qing Zhang, Beihua Kong
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2023-08-01
シリーズ:	Cell Reports
主題:	CP: Cancer CP: Immunology
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124723009555
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