De Novo Protein Design Enables Targeting of Intractable Oncogenic Protein–Protein Interfaces

Background/Objectives: Protein–protein interactions (PPIs) involving oncogenic drivers remain among the most intractable targets in cancer biology due to their dynamic conformations and limited accessibility to conventional small molecules. Although antibodies and inhibitors have achieved clinical s...

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Autori principali:	Varshika Ram Prakash, Yusuf Najy, Kalel Garrett, Brian F. P. Edwards, Benjamin L. Kidder
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-03-01
Serie:	Biologics
Soggetti:	de novo protein design computational binder design protein–protein interactions oncogenic protein interfaces hotspot mapping Molecular Operating Environment (MOE)
Accesso online:	https://www.mdpi.com/2673-8449/6/1/9
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