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De novo protein design: a transformative frontier in clinical protein applications

Abstract Background Protein biologics are indispensable in disease prevention, diagnosis, and therapy, yet their development remains largely constrained by reliance on native protein scaffolds, resulting in long development timelines, limited structural and functional tunability, challenges in manuf...

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主要な著者: Jie Gao, Zaiyong Zheng, Xueting Yu, Yamei Luo, Yang Yu, Chunxiang Zhang
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2026-02-01
シリーズ:Journal of Translational Medicine
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オンライン・アクセス:https://doi.org/10.1186/s12967-026-07784-0
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