Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1.
Brain and muscle arnt-like protein 1(BMAL1) is a critical regulator of circadian rhythm. Although transcriptional regulation of BMAL1 has been extensively studied, the mechanisms governing the stability of BMAL1 at the protein level remain unclear. p62/SQSTM1 is a crucial factor in proteostasis regu...
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| Principais autores: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science (PLoS)
2025-07-01
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| 叢編: | PLoS Genetics |
| 在線閱讀: | https://doi.org/10.1371/journal.pgen.1011794 |
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