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Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration

Ubiquitin (Ub), a central regulator of protein turnover, can be phosphorylated by PINK1 (PTEN-induced putative kinase 1) to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and in Parkinson’s disease, but the mechanistic link between pUb elevat...

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Principais autores: Cong Chen, Tong-Yao Gao, Hua-Wei Yi, Yi Zhang, Tong Wang, Zhi-Ling Lou, Tao-Feng Wei, Yun-Bi Lu, Tingting Li, Chun Tang, Wei-Ping Zhang
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2025-07-01
Serier:eLife
Fag:
PINK1
phosphorylation
proteasome
neurodegeneration
ubiquitin
Online adgang:https://elifesciences.org/articles/103945
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