Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system

Prolonged hyperglycemia plays a major role in the progression of β-cell loss in diabetes mellitus. Here we report an insulin sensitizer thiazolidinedione Pioglitazone selectively preserves the beta cells against high glucose-induced dysfunction by activation of AMPK and Glutaminase 1 (GLS1) axis. AM...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-09-01
Edice:	Redox Biology
Témata:	Pioglitazone AMPK Endoplasmic reticulum stress Oxidative stress Glutaminase Diabetes
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2213231721001877
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!