Induction of Glutathione Synthesis Provides Cardioprotection Regulating NO, AMPK and PPARa Signaling in Ischemic Rat Hearts

Glutathione (GSH) is essential for antioxidant defence, and its depletion is associated with tissue damage during cardiac ischemia-reperfusion (I/R). GSH is synthesized by the glutamate-cysteine ligase enzyme (GCL) from L-cysteine, which alternatively might be used for hydrogen sulfide production by...

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Hlavní autoři:	Yulia V. Goshovska, Raisa A. Fedichkina, Volodymyr V. Balatskyi, Oksana O. Piven, Pawel Dobrzyn, Vadym F. Sagach
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-06-01
Edice:	Life
Témata:	cardioprotection glutathione ischemia heart SERCA AMPK
On-line přístup:	https://www.mdpi.com/2075-1729/11/7/631
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