Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Abstract Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer’s disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation properties of Aβ. We recently identified the Uppsala APP mutation (APPUpp), which...

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Autores principales:	María Pagnon de la Vega, Stina Syvänen, Vilmantas Giedraitis, Monique Hooley, Evangelos Konstantinidis, Silvio R. Meier, Johanna Rokka, Jonas Eriksson, Ximena Aguilar, Tara L. Spires-Jones, Lars Lannfelt, Lars N. G. Nilsson, Anna Erlandsson, Greta Hultqvist, Martin Ingelsson, Dag Sehlin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2024-02-01
Colección:	Acta Neuropathologica Communications
Materias:	Alzheimer’s disease (AD) Amyloid precursor protein (APP) Amyloid-beta (Aβ) PET imaging Microglia Astrocytes
Acceso en línea:	https://doi.org/10.1186/s40478-024-01734-x
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