Development and characterization of a human papillomavirus-based nanoparticle carrier for heterologous vaccine antigens

Abstract The display of a repetitive array of antigens on the surface of nanoparticles has been shown to effectively trigger the activation of cognate B cells and to increase humoral immune responses. Building on extensive knowledge from the development and clinical use of virus-like particle (VLP)...

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Bibliografiske detaljer

Principais autores:	Yu Wang, Nils Bartelsen, Philipp Arnold, Sandra Mueller-Schmucker, Christoph Weingärtner, Jannis Beutel, Jutta Eichler, Vladimir Temchura, Dominik Damm, Klaus Überla
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-09-01
Serier:	Scientific Reports
Fag:	Virus-like particle (VLP) T helper nanoparticles HIV vacciner Env trimer B cell activation Humoral immune response
Online adgang:	https://doi.org/10.1038/s41598-025-19009-3
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