Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis

Abstract The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function. The challenge has been to deliver siRNA to the lung with sufficient efficacy for a sustained the...

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Hlavní autoři:	Maria D. I. Manunta, Aristides D. Tagalakis, Martin Attwood, Ahmad M. Aldossary, Josephine L. Barnes, Mustafa M. Munye, Alexander Weng, Robin J McAnulty, Stephen L. Hart
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2017-04-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-017-00662-2
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