Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis

Abstract The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function. The challenge has been to deliver siRNA to the lung with sufficient efficacy for a sustained the...

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Detalhes bibliográficos

Principais autores:	Maria D. I. Manunta, Aristides D. Tagalakis, Martin Attwood, Ahmad M. Aldossary, Josephine L. Barnes, Mustafa M. Munye, Alexander Weng, Robin J McAnulty, Stephen L. Hart
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2017-04-01
Colecção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-017-00662-2
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