Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.

Mutations in the epidermal growth factor receptor (EGFR) gene are associated with increased sensitivity of lung cancers to kinase inhibitors like erlotinib. Mechanisms of cell death that occur after kinase inhibition in these oncogene-dependent tumors have not been well delineated. We sought to impr...

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Detalles Bibliográficos

Principais autores:	Yixuan Gong, Romel Somwar, Katerina Politi, Marissa Balak, Juliann Chmielecki, Xuejun Jiang, William Pao
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2007-10-01
Series:	PLoS Medicine
Acceso en liña:	http://europepmc.org/articles/PMC2001209?pdf=render
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