Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.

Mutations in the epidermal growth factor receptor (EGFR) gene are associated with increased sensitivity of lung cancers to kinase inhibitors like erlotinib. Mechanisms of cell death that occur after kinase inhibition in these oncogene-dependent tumors have not been well delineated. We sought to impr...

Повний опис

Бібліографічні деталі

Автори:	Yixuan Gong, Romel Somwar, Katerina Politi, Marissa Balak, Juliann Chmielecki, Xuejun Jiang, William Pao
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Public Library of Science (PLoS) 2007-10-01
Серія:	PLoS Medicine
Онлайн доступ:	http://europepmc.org/articles/PMC2001209?pdf=render
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!