KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.

<h4>Background</h4>Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in...

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Autors principals:	William Pao, Theresa Y Wang, Gregory J Riely, Vincent A Miller, Qiulu Pan, Marc Ladanyi, Maureen F Zakowski, Robert T Heelan, Mark G Kris, Harold E Varmus
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2005-01-01
Col·lecció:	PLoS Medicine
Accés en línia:	https://doi.org/10.1371/journal.pmed.0020017
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