A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia.

PspA and pneumolysin are two important vaccine candidates, able to elicit protection in different models of pneumococcal infection. The high immunogenic potential of PspA, combined with a possible adjuvant effect of pneumolysin derivatives (due to their ability to interact with TLR-4) could greatly...

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Principais autores:	Tanila Wood Dos Santos, Pedro Almeida Gonçalves, Dunia Rodriguez, José Aires Pereira, Carlos Augusto Real Martinez, Luciana C C Leite, Lucio F C Ferraz, Thiago Rojas Converso, Michelle Darrieux
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2022-01-01
Serija:	PLoS ONE
Online dostop:	https://doi.org/10.1371/journal.pone.0277304
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