A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia.

PspA and pneumolysin are two important vaccine candidates, able to elicit protection in different models of pneumococcal infection. The high immunogenic potential of PspA, combined with a possible adjuvant effect of pneumolysin derivatives (due to their ability to interact with TLR-4) could greatly...

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Bibliografische Detailangaben

Hauptverfasser:	Tanila Wood Dos Santos, Pedro Almeida Gonçalves, Dunia Rodriguez, José Aires Pereira, Carlos Augusto Real Martinez, Luciana C C Leite, Lucio F C Ferraz, Thiago Rojas Converso, Michelle Darrieux
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2022-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://doi.org/10.1371/journal.pone.0277304
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