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GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins

Golgi-associated retrograde protein (GARP) is an evolutionary conserved heterotetrameric protein complex that tethers endosome-derived vesicles and is vital for Golgi glycosylation. Microscopy and proteomic approaches were employed to investigate defects in Golgi physiology in RPE1 cells depleted fo...

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Auteurs principaux: Amrita Khakurel, Tetyana Kudlyk, Irina Pokrovskaya, Zinia D’Souza, Vladimir V. Lupashin
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2022-12-01
Collection:Frontiers in Cell and Developmental Biology
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Accès en ligne:https://www.frontiersin.org/articles/10.3389/fcell.2022.1066504/full
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