A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without interfering with bleeding time

Highlights • Venom-analog peptide, (p-BthTX-I)2K, inhibits SARS-CoV-2 infection and papain-like protease. • Bothropstoxin-I-derived peptide analog shows antithrombotic action. • (p-BthTX-I)2K prolonged aPTT and PT by blocking kallikrein and factor Xa. • Venom-analog peptide, (p-BthTX-I)2K, shows ant...

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Auteurs principaux:	Ruben Siedlarczyk Nogueira, Bruno Ramos Salu, Vinícius Goulart Nardelli, Camila Ramalho Bonturi, Marina Rodrigues Pereira, Francisco Humberto de Abreu Maffei, Eduardo Maffud Cilli, Maria Luiza Vilela Oliva
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2023-01-01
Collection:	Thrombosis Journal
Sujets:	Bleeding COVID-19 Cysteine-protease Papain-like protease Platelets SARS-CoV-2
Accès en ligne:	https://doi.org/10.1186/s12959-022-00436-5
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