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Protein Misfolding and Aggregation as a Mechanistic Link Between Chronic Pain and Neurodegenerative Diseases

Chronic pain, defined by persistent pain beyond normal healing time, is a pervasive and debilitating condition affecting up to 30–50% of adults globally. In parallel, neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS)...

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Principais autores: Nebojsa Brezic, Strahinja Gligorevic, Aleksandar Sic, Nebojsa Nick Knezevic
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2025-04-01
Series:Current Issues in Molecular Biology
Assuntos:
chronic pain
neurodegenerative diseases
protein misfolding
protein aggregation
unfolded protein response
endoplasmic reticulum stress
Acceso en liña:https://www.mdpi.com/1467-3045/47/4/259
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