Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo

Drug resistance: Overcoming localized resistance to anti-HER2 therapy Location-specific subpopulations of breast cancer cells adapt to targeted drug treatment, but therapeutic strategies exist to attack these niche-protected cells. A team led by Joan Brugge and Jason Zoeller from Harvard Medical Sch...

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Hlavní autoři:	Jason J. Zoeller, Roderick T. Bronson, Laura M. Selfors, Gordon B. Mills, Joan S. Brugge
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2017-05-01
Edice:	npj Breast Cancer
On-line přístup:	https://doi.org/10.1038/s41523-017-0020-z
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