Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione

ABSTRACT Acetaminophen (APAP), an over‐the‐counter analgesic and antipyretic, can cause hepatotoxicity when ingested in large overdoses. APAP has multiple formulations including immediate‐release (IR) and extended‐release (ER) preparations. A recently published consensus statement on the management...

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Principais autores:	Kyunghee Yang, James J. Beaudoin, Brett A. Howell, James Mullin, Elham Amini, John C. K. Lai, Cathy K. Gelotte, Sury Sista, Evren Atillasoy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-07-01
coleção:	CPT: Pharmacometrics & Systems Pharmacology
Assuntos:	acetaminophen extended release liver safety quantitative systems toxicology modeling
Acesso em linha:	https://doi.org/10.1002/psp4.70045
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