Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione

ABSTRACT Acetaminophen (APAP), an over‐the‐counter analgesic and antipyretic, can cause hepatotoxicity when ingested in large overdoses. APAP has multiple formulations including immediate‐release (IR) and extended‐release (ER) preparations. A recently published consensus statement on the management...

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Autori principali:	Kyunghee Yang, James J. Beaudoin, Brett A. Howell, James Mullin, Elham Amini, John C. K. Lai, Cathy K. Gelotte, Sury Sista, Evren Atillasoy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-07-01
Serie:	CPT: Pharmacometrics & Systems Pharmacology
Soggetti:	acetaminophen extended release liver safety quantitative systems toxicology modeling
Accesso online:	https://doi.org/10.1002/psp4.70045
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