Ablating Satb1 reprograms the differentiation trajectory of exhausted CD8+ T subsets to enhance antitumor immunity

IntroductionUnder chronic infections or in tumors, persistent antigen exposure drives CD8+ T cell exhaustion, a heterogeneous state encompassing a differentiation continuum from stem-like progenitor (Tpex) cells through transitory effector-like (Tex-int) cells to terminally exhausted (Tex-term) subs...

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Principais autores:	Linwei Wu, Haolin Jiang, Jianling Gao, Xiaolan Ji, Yu Chen, Zhenghao Ma, Xinying Li, Jin Wang, Yachen Zang, Ji Zhang, Xin Zhao, Xuefeng Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-06-01
Series:	Frontiers in Immunology
Assuntos:	effector-like Tex- int cells Satb1 stem-like Tpex cells Tex-int cells Tpex cells tumor immunity
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1744549/full
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