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Ablating Satb1 reprograms the differentiation trajectory of exhausted CD8+ T subsets to enhance antitumor immunity

IntroductionUnder chronic infections or in tumors, persistent antigen exposure drives CD8+ T cell exhaustion, a heterogeneous state encompassing a differentiation continuum from stem-like progenitor (Tpex) cells through transitory effector-like (Tex-int) cells to terminally exhausted (Tex-term) subs...

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Principais autores: Linwei Wu, Haolin Jiang, Jianling Gao, Xiaolan Ji, Yu Chen, Zhenghao Ma, Xinying Li, Jin Wang, Yachen Zang, Ji Zhang, Xin Zhao, Xuefeng Wang
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2026-06-01
סדרה:Frontiers in Immunology
נושאים:
effector-like Tex- int cells
Satb1
stem-like Tpex cells
Tex-int cells
Tpex cells
tumor immunity
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1744549/full
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