A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies

Abstract A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐N‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, (T‐1‐APFPB), following the pharmacophoric features of VEGFR‐2 inhibitors. The stability and reactivity of T‐1‐A...

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Autori principali:	Prof. Ibrahim H. Eissa, Reda G. Yousef, Dr. Hazem Elkady, Dr. Eslam B. Elkaeed, Dr. Aisha A. Alsfouk, Dr. Dalal Z. Husein, Ibrahim M. Ibrahim, Prof. Mohamed M. Radwan, Prof. Ahmed M. Metwaly
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley-VCH 2023-10-01
Serie:	ChemistryOpen
Soggetti:	apoptosis CAAD DFT MD simulations VEGFR-2
Accesso online:	https://doi.org/10.1002/open.202300066
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