A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies

Abstract A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐N‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, (T‐1‐APFPB), following the pharmacophoric features of VEGFR‐2 inhibitors. The stability and reactivity of T‐1‐A...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Prof. Ibrahim H. Eissa, Reda G. Yousef, Dr. Hazem Elkady, Dr. Eslam B. Elkaeed, Dr. Aisha A. Alsfouk, Dr. Dalal Z. Husein, Ibrahim M. Ibrahim, Prof. Mohamed M. Radwan, Prof. Ahmed M. Metwaly
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Wiley-VCH 2023-10-01
Цуврал:	ChemistryOpen
Нөхцлүүд:	apoptosis CAAD DFT MD simulations VEGFR-2
Онлайн хандалт:	https://doi.org/10.1002/open.202300066
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!