HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of different isoforms. P1-HNF4α is the major isoform in the adult liver while P2-HNF4α is thought to be expressed only in fetal liver and liver...

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Detalhes bibliográficos

Principais autores:	Jonathan R. Deans, Poonamjot Deol, Nina Titova, Sarah H. Radi, Linh M. Vuong, Jane R. Evans, Songqin Pan, Johannes Fahrmann, Jun Yang, Bruce D. Hammock, Oliver Fiehn, Baharan Fekry, Kristin Eckel-Mahan, Frances M. Sladek
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-12-01
coleção:	Frontiers in Endocrinology
Assuntos:	cytochrome P450 metabolic switch sex-specific gene expression fasting circadian clock ketogenesis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1266527/full
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