ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence

ABSTRACT Zika virus (ZIKV) is a mosquito-borne Flavivirus that persistently infects patients; enters protected brain, placental, and testicular compartments; is sexually transmitted; and causes fetal microcephaly in utero. ZIKV persistently infects human brain microvascular endothelial cells (hBMECs...

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Principais autores:	William R. Schutt, Jonas N. Conde, Megan C. Mladinich, Grace E. Himmler, Erich R. Mackow
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2023-10-01
coleção:	mBio
Assuntos:	Zika virus tristetraprolin endothelial cells Sertoli cells interferon regulation persistence
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.01742-23
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