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The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

TRAAK is a membrane tension-activated K+ channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating elements of myelinated nerv...

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Autori principali: Stephen G Brohawn, Weiwei Wang, Annie Handler, Ernest B Campbell, Jürgen R Schwarz, Roderick MacKinnon
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2019-11-01
Serie:eLife
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Accesso online:https://elifesciences.org/articles/50403
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