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The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

TRAAK is a membrane tension-activated K+ channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating elements of myelinated nerv...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stephen G Brohawn, Weiwei Wang, Annie Handler, Ernest B Campbell, Jürgen R Schwarz, Roderick MacKinnon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications Ltd 2019-11-01
Cyfres:eLife
Pynciau:
Mynediad Ar-lein:https://elifesciences.org/articles/50403
Tagiau: Ychwanegu Tag
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