Electroporation Enhanced Effect of Dystrophin Splice Switching PNA Oligomers in Normal and Dystrophic Muscle

Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been reported. As a possible modality for improvem...

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Bibliografske podrobnosti

Principais autores:	Camilla Brolin, Takehiko Shiraishi, Pernille Hojman, Thomas O Krag, Peter E Nielsen, Julie Gehl
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2015-01-01
Serija:	Molecular Therapy: Nucleic Acids
Teme:	antisense electroporation exon skipping mdx PNA splicing modulation
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2162253116300531
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