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518 Modeling of cancer mutations found in pediatric DICER1 syndrome informs novel therapeutic targeting strategies

Objectives/Goals: Large-scale tumor sequencing efforts have led to annotations of novel cancer hotspot mutations that may underlie driver or cooperative function. We have sought to define the molecular consequences of such hotspots associated with pediatric DICER1 syndrome cancers, with the ultimate...

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Bibliografische gegevens
Hoofdauteurs: David Jee, Seungjae Lee, Dapeng Yang, Robert Rickert, Renfu Shang, Danwei Huangfu, Eric C. Lai
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cambridge University Press 2025-04-01
Reeks:Journal of Clinical and Translational Science
Online toegang:https://www.cambridge.org/core/product/identifier/S2059866124010987/type/journal_article
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