N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease

Abstract Background Tauopathies are a group of neurodegenerative diseases, including Alzheimer’s disease (AD), characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau species, truncated variants are emerging as key contributors, yet their identity remains elusiv...

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Bibliografische Detailangaben

Hauptverfasser:	Sarah Guedjdal, Coline Leghay, Maxime Derisbourg, Sabiha Eddarkaoui, Simon Lecerf, Florian Vermon, Raphaelle Caillierez, Séverine Begard, Claire Regost, Charlotte Laloux, Paulo J. da Costa, Kevin Carvalho, Giovanni Chiappetta, Yann Verdier, Valérie Buée-Scherrer, Vincent Deramecourt, Susanna Schraen, David Blum, Franck Martin, Luc Buée, Malika Hamdane
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-04-01
Schriftenreihe:	Translational Neurodegeneration
Schlagworte:	Tau modifications Tau truncation Neurofibrillary degeneration Tauopathies Passive immunotherapy
Online-Zugang:	https://doi.org/10.1186/s40035-026-00550-8
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