Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease

Abstract Background Tauopathies are neurodegenerative diseases all characterized by tau lesions in the brain. Nevertheless, a clinical and pathophysiological heterogeneity is present among them. This includes the dominant tau isoform found within aggregates (3R and/or 4R tau) along with different br...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Marie Oosterlynck, Laura Fichter, Elodie Leroux, Sabiha Eddarkaoui, Thomas Bouillet, Camille Lefebvre, Marine Nguyen, Claude-Alain Maurage, Bertrand Accart, Elian Dupré, Isabelle Landrieu, Clément Danis, Sylvain Lehmann, Jérôme Vialaret, Luc Buée, Christophe Hirtz, Morvane Colin
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	BMC 2026-06-01
سلاسل:	Journal of Biomedical Science
الموضوعات:	Tauopathies Alzheimer’s disease Extracellular Vesicles Seeding Tau proteoforms PHF6 peptide
الوصول للمادة أونلاين:	https://doi.org/10.1186/s12929-026-01250-1
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!