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Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease

Abstract Background Tauopathies are neurodegenerative diseases all characterized by tau lesions in the brain. Nevertheless, a clinical and pathophysiological heterogeneity is present among them. This includes the dominant tau isoform found within aggregates (3R and/or 4R tau) along with different br...

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Автори: Marie Oosterlynck, Laura Fichter, Elodie Leroux, Sabiha Eddarkaoui, Thomas Bouillet, Camille Lefebvre, Marine Nguyen, Claude-Alain Maurage, Bertrand Accart, Elian Dupré, Isabelle Landrieu, Clément Danis, Sylvain Lehmann, Jérôme Vialaret, Luc Buée, Christophe Hirtz, Morvane Colin
Формат: Artigo
Мова:Inglês
Опубліковано: BMC 2026-06-01
Серія:Journal of Biomedical Science
Предмети:
Tauopathies
Alzheimer’s disease
Extracellular Vesicles
Seeding
Tau proteoforms
PHF6 peptide
Онлайн доступ:https://doi.org/10.1186/s12929-026-01250-1
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