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miR-374-5p inhibits osteogenesis by targeting PTEN/PI3K/AKT signaling pathway

Abstract Purpose This study aims to evaluate the effects of miR-374-5p on osteogenesis in rat osteoblasts, validate its target on PTEN, and explore its role in the PTEN/PI3K/AKT signaling pathway during osteoblast differentiation. Methods We transfected 293T cells with miR-374-5p mimics and inhibito...

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Príomhchruthaitheoirí: Guangning Long, Fen Liu, Hongmeng Cheng, Jun Guo, Pei Wang, Yunfei Luo, Zhihua Li, Fei Tong
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: BMC 2025-03-01
Sraith:Journal of Orthopaedic Surgery and Research
Ábhair:
Rochtain ar líne:https://doi.org/10.1186/s13018-025-05670-x
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