MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function

Abstract Background Foxp3+CD4+ regulatory T cells (Treg) constitutes a key event in autoimmune diseases. STAT5b is the critical link between the IL-2/15 and FOXP3, the master regulator of Treg cells. Methods The CD3+T cell and Foxp3+CD4+ regulatory T cells were overexpressioned or knockdown MKL-1 an...

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Detalhes bibliográficos

Principais autores:	Yuan Xiang, Jun Wang, Jia Peng Li, Wei Guo, Feng Huang, Hui Min Zhang, Han Han Li, Zhou Tong Dai, Zi Jian Zhang, Hui Li, Le Yuan Bao, Chao Jiang Gu, Kun Chen, Tong Cun Zhang, Xing Hua Liao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-07-01
Colecção:	Cell Communication and Signaling
Assuntos:	MKL-1 STAT5b Treg ITP
Acesso em linha:	http://link.springer.com/article/10.1186/s12964-020-00574-1
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