Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent

This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis th...

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Autori principali:	Roberto E.P. Sica, Alejandro F. De Nicola, María C. González Deniselle, Gabriel Rodriguez, Gisella M. Gargiulo Monachelli, Liliana Martinez Peralta, Mariela Bettini
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Thieme Revinter Publicações 2011-08-01
Serie:	Arquivos de Neuro-Psiquiatria
Soggetti:	esclerosis lateral amiotrófica esclerosis lateral amiotrófica esporádica patogenia astrocito
Accesso online:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500023&lng=en&tlng=en
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