Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent

This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis th...

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主要な著者:	Roberto E.P. Sica, Alejandro F. De Nicola, María C. González Deniselle, Gabriel Rodriguez, Gisella M. Gargiulo Monachelli, Liliana Martinez Peralta, Mariela Bettini
フォーマット:	Artigo
言語:	Inglês
出版事項:	Thieme Revinter Publicações 2011-08-01
シリーズ:	Arquivos de Neuro-Psiquiatria
主題:	esclerosis lateral amiotrófica esclerosis lateral amiotrófica esporádica patogenia astrocito
オンライン･アクセス:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500023&lng=en&tlng=en
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