Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine derivatives as inhibitors of oncogenic kinases. The design was inspired by the chemical structures of well-known kinase inhibitors and our previou...

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Hlavní autoři:	Jeanluc Bertrand, Hana Dostálová, Vladimír Kryštof, Radek Jorda, Thalía Delgado, Alejandro Castro-Alvarez, Jaime Mella, David Cabezas, Mario Faúndez, Christian Espinosa-Bustos, Cristian O. Salas
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-06-01
Edice:	Pharmaceutics
Témata:	leukaemia purine derivatives tyrosine kinases inhibitors 3D-QSAR molecular docking
On-line přístup:	https://www.mdpi.com/1999-4923/14/6/1294
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