QR Code

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine derivatives as inhibitors of oncogenic kinases. The design was inspired by the chemical structures of well-known kinase inhibitors and our previou...

Full description

Saved in:
Main Authors: Jeanluc Bertrand, Hana Dostálová, Vladimír Kryštof, Radek Jorda, Thalía Delgado, Alejandro Castro-Alvarez, Jaime Mella, David Cabezas, Mario Faúndez, Christian Espinosa-Bustos, Cristian O. Salas
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
leukaemia
purine derivatives
tyrosine kinases inhibitors
3D-QSAR
molecular docking
Online Access:https://www.mdpi.com/1999-4923/14/6/1294
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items