VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

Mutations in vacuolar protein sorting 35 (VPS35) have been linked to familial Parkinson's disease (PD). VPS35, a component of the retromer, mediates the retrograde transport of cargo from the endosome to the trans-Golgi network. Here we showed that retromer depletion increases the lysosomal turnover...

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Autori principali:	Emiko Miura, Takafumi Hasegawa, Masatoshi Konno, Mari Suzuki, Naoto Sugeno, Nobuhiro Fujikake, Sven Geisler, Mitsuaki Tabuchi, Ryuji Oshima, Akio Kikuchi, Toru Baba, Keiji Wada, Yoshitaka Nagai, Atsushi Takeda, Masashi Aoki
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2014-11-01
Serie:	Neurobiology of Disease
Soggetti:	Parkinson's disease VPS35 α-Synuclein Retromer Cathepsin D Lysosome
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0969996114002150
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