Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin

Abstract Objective Acute kidney injury (AKI) occurs in approximately one-third of patients treated with cisplatin and there is an outstanding need for mitigation strategies to decrease the frequency and severity of cisplatin-induced AKI. This study evaluated bardoxolone methyl (BARD) as a nephroprot...

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Principais autores:	Lauren E. Thompson, Stacey M. Tuey, Paola Garcia Gonzalez, Carly S. Chesterman, Courtney D. McGinnis, M. Scott Lucia, Lauren M. Aleksunes, Charles L. Edelstein, Melanie S. Joy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2025-03-01
coleção:	AAPS Open
Assuntos:	Cisplatin Nephrotoxicity Bardoxolone Methyl Acute Kidney Injury Nrf2
Acesso em linha:	https://doi.org/10.1186/s41120-025-00107-5
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